Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
نویسندگان
چکیده
منابع مشابه
Dysregulation of the levels of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the early phase of cerebral ischemia.
Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in the Early Phase of Cerebral Ischemia To the Editor: Castellanos et al1 reported increased matrix metalloproteinase (MMP)-9 plasma levels to be an independent risk factor for hemorrhagic transformation in all stroke subtypes. Plasma levels of MMP-9 in patients without hemorrhage were not significantly different from control...
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Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
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متن کاملMatrix Metalloproteinases in Cerebral Ischemia
Matrix metalloproteinases (MMPs) are involved in the pathophysiology of several central nervous system diseases that share common pathogeneses, such as disruption of the blood-brain barrier (BBB), neuroinflammation, oxidative stress, and remodeling of the extracellular matrix (ECM). In early ischemic injury, MMPs participate in disruption of the BBB by digesting the basal lamina of capillaries ...
متن کاملMatrix metalloproteinases in neuroinflammation.
Matrix metalloproteinases (MMPs) are a gene family of neutral proteases that are important in normal development, wound healing, and a wide variety of pathological processes, including the spread of metastatic cancer cells, arthritic destruction of joints, atherosclerosis, and neuroinflammation. In the central nervous system (CNS), MMPs have been shown to degrade components of the basal lamina,...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2009
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2008.06.025